PLAVIX (clopidogrel bisulfate) 75mg tablets

What Important Risk Information should I know?

Certain genetic factors and some medicines such as Prilosec reduce the effect of PLAVIX, leaving you at greater risk for heart attack and stroke. Your doctor may use genetic tests to determine treatment.

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What are some possible serious side effects that may occur when taking PLAVIX or PLAVIX with aspirin?

Taking PLAVIX alone or with some other medicines, including aspirin, may increase bleeding risk, so tell your doctor when planning surgery. Tell your doctor all medicines you take, including aspirin, especially if you’ve had a stroke. If fever, unexplained weakness or confusion develops, tell your doctor promptly. These may be signs of TTP, a rare but potentially life-threatening condition, reported sometimes less than 2 weeks after starting PLAVIX.

What are the symptoms of TTP?

• purplish spots (called purpura) on the skin or in the mouth (mucous membranes) due to bleeding under the skin
• your skin or the whites of your eyes are yellow (jaundice)
• you feel tired or weak
• your skin looks very pale
• fever
• fast heart rate or feeling short of breath
• headache
• speech changes
• confusion
• coma
• stroke
• seizure
• low amount of urine, or urine that is pink or has blood in it
• stomach area (abdominal) pain
• nausea, vomiting, or diarrhea
• vision changes

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor right away if you have any of these signs or symptoms of bleeding:

• unexpected bleeding or bleeding that lasts a long time
• blood in your urine (pink, red or brown urine)
• red or black stools (looks like tar)
• bruises that happen without a known cause or get larger
• cough up blood or blood clots
• vomit blood or your vomit looks like coffee grounds

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Stent* or no stent, could PLAVIX be right for me?

Some patients who have had heart-related chest pain (unstable angina) or a certain type of heart attack in which their artery was partially blocked (non–ST-segment elevation heart attack) have medical procedures to insert a stent into an artery that is narrowed due to plaque buildup. Others are managed with medical treatment or with cardiac surgery. In each of these cases, it's still important to talk to your doctor and get the PLAVIX information you need. Doctors may refer to these conditions as ACS (Acute Coronary Syndrome).

_{*Bare metal stents. If you have any other type of stent, please talk to your doctor.}

How is PLAVIX different from my other heart medicines?

Although blood pressure and cholesterol medicines reduce your overall cardiovascular risk, they do not directly prevent clot formation—the cause of most heart attacks and strokes. Prescription PLAVIX does.

For more than 13 years, doctors have written PLAVIX prescriptions to over 115 million people. PLAVIX is the #1 prescribed antiplatelet medicine.* PLAVIX has been the focus of extensive research, studies, and scientific findings. The effectiveness of PLAVIX has been proven and the safety profile supported by 3 large clinical studies involving 77,000 patients.

* IMS Health, NPA Plus^™, TRxs. February 2010.

Your doctor may prescribe daily PLAVIX and aspirin if you have been hospitalized with heart-related chest pain (unstable angina) or had a heart attack. Doctors may refer to these conditions as ACS (Acute Coronary Syndrome). Review any medicines you are taking with your doctor, and always check with your doctor before stopping or starting any prescription or over-the-counter medicine, or any herbal or dietary supplements.

How can I find out more about heart health?

Remember, your doctor is the single best source for answers to your heart attack questions and information regarding PLAVIX and your health. Please consult your doctor if you have any questions about your health or medicine.

For additional information, you can also learn more from The American Heart Association.