PLAVIX Research

Understanding Heart Medications

Learn About Cardiovascular Treatment Options

There are several types of heart medications. Learning how these medications work will help you and your doctor discuss which ones may be right for you.

Plavix: clopidogrel bisulfate; 75mg tablets

Video: how PLAVIX works.How it works: Proven to help reduce the risk of platelets from sticking together and forming clots, which can help protect against a future heart attack or stroke.

What it targets: Clots that form in the arteries are the direct cause of more than 90% of heart attacks and 87% of strokes.

Once you have had a heart attack or stroke, your risk of a heart attack or stroke never goes away, even if you feel better.

PLAVIX, a prescription-only medicine, is for patients who have had a recent heart attack, had a recent stroke, or have been diagnosed with Peripheral Artery Disease. PLAVIX in combination with aspirin is for patients hospitalized with heart-related chest pain or heart attack. Doctors may refer to these conditions as ACS (Acute Coronary Syndrome). Always talk to your doctor before taking aspirin or other medicines with PLAVIX, especially if you've had a stroke.

Plavix: clopidogrel bisulfate; 75mg tablets

A heart medication prescribed for millions.

For more than 13 years, doctors have written PLAVIX prescriptions to over 115 million people.* PLAVIX, taken daily, can help protect you if you've had a recent heart attack or stroke, or if you have P.A.D. (also known as poor circulation in the legs).† Taking PLAVIX can help reduce your risk of a future heart attack or stroke. PLAVIX continues to help protect you as long as you take it as your doctor prescribes. Talk to your doctor before taking aspirin or other medicines with PLAVIX, especially if you've had a stroke. PLAVIX is not indicated for the treatment of symptoms of P.A.D.

*IMS Health, NPA Plus, TRxs. February 2010.
PLAVIX helps keep blood platelets from sticking together and forming clots, the cause of most heart attacks and strokes.

Click here for US Full Prescribing Information Including BOXED WARNING and Medication Guide

Aspirin

Aspirin works by stopping the production of certain natural substances that cause fever, pain and swelling. Aspirin is also used as a heart medication to help reduce the tendency for blood to form clots.

How it works: Aspirin works by stopping the production of certain natural substances that cause fever, pain and swelling. Aspirin is also used as a heart medication to help reduce the tendency for the blood to form clots.

What it targets: Aspirin is used to help prevent heart attacks or strokes in people who have had a heart attack or stroke in the past.

If you've been hospitalized with heart-related chest pain, or had a heart attack, PLAVIX, taken with aspirin, helps provide more protection against a future heart attack or stroke than aspirin alone.

Taking PLAVIX alone or with some other medicines, including aspirin, may increase bleeding risk, so tell your doctor when planning surgery.

Diuretics

Drugs that work by increasing the rate at which urine forms, which helps with the removal of water and salts.How they work: Drugs that work by increasing the rate at which urine forms, which helps with the removal of water and salts.

What they target: Help to relieve the heart's workload and also decrease the buildup of fluid in the lungs and other parts of the body, such as the ankles and legs. Diuretics are heart medications used to treat high blood pressure, congestive heart failure, and some congenital heart defects.

Diuretics such as:

• Bumetanide (Bumex®)

• Hydrochlorothiazide (Hydrodiuril®)

• Indapamide (Lozol®)

• Spironolactone (Aldactone®)

The brands listed are the registered trademarks of
their respective owners and are not trademarks of
Bristol-Myers Squibb Company, sanofi-aventis U.S. LLC,
or the Bristol-Myers Squibb/Sanofi Pharmaceuticals Partnership.

Beta-blockers

A class of heart medications that slow the heartbeat, lessen the force with which the heart muscle contracts and reduce the narrowing of blood vessels in the heart, brain, and throughout the body.

How they work: A class of heart medications that slow the heartbeat, lessen the force with which the heart muscle contracts and reduce the narrowing of blood vessels in the heart, brain, and throughout the body.

What they target: Beta-blockers are heart medications that relieve stress on the heart by acting on substances in the blood. They may be used to treat abnormal heart rhythms and prevent abnormally fast heart rates. They may also be useful in treating chest pain and treating high blood pressure and other heart conditions by reducing the heart rate and the heart's output of blood.

Beta-blockers such as:

• Atenolol (Tenormin®)

• Betaxolol (Kerlone®)

• InsoAcebutolol (Sectral®)

• Metoprolol (Lopressor®)

• Sotalol (Betapace®)

The brands listed are the registered trademarks of
their respective owners and are not trademarks of
Bristol-Myers Squibb Company, sanofi-aventis U.S. LLC,
or the Bristol-Myers Squibb/Sanofi Pharmaceuticals Partnership.

Calcium Channel Blockers

A class of heart medications that block the movement of calcium into the heart and blood vessel muscle cells.

How they work: A class of heart medications that block the movement of calcium into the heart and blood vessel muscle cells. This causes the muscles to relax, lowering blood pressure, slowing the heart rate, and decreasing the heart's oxygen demands.

What they target: These heart medications lower blood pressure in patients with hypertension. They decrease the heart's pumping strength, slow the heart rate, and relax blood vessels. They are also used to treat other heart conditions, such as chest pain and abnormal heart rhythms.

Calcium Channel Blockers such as:

• Amlodipine (Lotrel®)

• Diltiazem (Tiazac®)

• Felodipine (Plendil®)

• Nifedipine (Adalat®)

• Verapamil (Verelan®)

The brands listed are the registered trademarks of
their respective owners and are not trademarks of
Bristol-Myers Squibb Company, sanofi-aventis U.S. LLC,
or the Bristol-Myers Squibb/Sanofi Pharmaceuticals Partnership.

ACE Inhibitors/ARB Blockers

ACE inhibitors act as heart medications to stop the body's production of angiotensin. ARB blockers stop the effects of angiotensin.How they work: ACE inhibitors act as heart medications to stop the body's production of angiotensin. ARB blockers stop the effects of angiotensin.

What they target: Both of these classes of heart medications are used to treat high blood pressure and heart failure by targeting a chemical called angiotensin, which causes blood vessels to narrow. Both help keep the coronary arteries open, which lowers blood pressure, increases blood flow to the heart, and reduces the heart's workload.

ACE Inhibitors/ARB Blockers such as:

• Benazepril (Lotensin®)

• Fosinopril (Monopril®)

• Lisinopril (Zestril®)

• Perindopril (Aceon®)

• Ramipril (Altace®)

The brands listed are the registered trademarks of
their respective owners and are not trademarks of
Bristol-Myers Squibb Company, sanofi-aventis U.S. LLC,
or the Bristol-Myers Squibb/Sanofi Pharmaceuticals Partnership.

Statins

Statins are a class of heart medications that lower the amount of cholesterol in the blood.How they work: Statins are a class of heart medications that lower the amount of cholesterol in the blood.

What they target: Most cholesterol is carried through the blood in a protein "package" called low-density lipoprotein (LDL). LDL is considered the "bad" cholesterol because it is most likely to be deposited in the artery walls, increasing the buildup of plaque and the potential for clots.

Statins such as:

• Atorvastatin (Lipitor®)

• Fluvastatin (Lescol®)

• Lovastatin

• Pravastatin

• Simvastatin

• Simvastatin/ezetimibe (Vytorin®)

The brands listed are the registered trademarks of
their respective owners and are not trademarks of
Bristol-Myers Squibb Company, sanofi-aventis U.S. LLC,
or the Bristol-Myers Squibb/Sanofi Pharmaceuticals Partnership.

Leg Pain Symptom Relievers

These medications are used for the treatment of patients with cramp-like symptoms in their legs.How they work: These medications are used for the treatment of patients with cramp-like symptoms in their legs. They help improve the flow of blood in the legs by lessening its thickness or by dilating the arteries in the legs.

What they target: Help increase blood flow to the affected areas and improve the level of oxygen getting to the tissues. These medications can help relieve the symptoms of P.A.D. but, unlike PLAVIX, they are not indicated to help reduce the risk of heart attack and stroke associated with P.A.D. PLAVIX is not indicated for the treatment of symptoms of P.A.D.

Leg Pain Symptom Relievers such as:

• Cilostazol (Pletal®)

• Pentoxifylline (Trental®)

The brands listed are the registered trademarks of
their respective owners and are not trademarks of
Bristol-Myers Squibb Company, sanofi-aventis U.S. LLC,
or the Bristol-Myers Squibb/Sanofi Pharmaceuticals Partnership.

IMPORTANT SAFETY INFORMATION ABOUT PLAVIX
Certain genetic factors and some medicines such as Prilosec reduce the effect of PLAVIX leaving you at greater risk for heart attack and stroke. Your doctor may use genetic tests to determine treatment. Don’t stop taking PLAVIX without talking to your doctor as your risk of heart attack or stroke may increase. People with stomach ulcers or conditions that cause bleeding should not use PLAVIX. Taking PLAVIX alone or with some other medicines, including aspirin, may increase bleeding risk which can potentially be life-threatening. So tell your doctor when planning surgery. Tell your doctor all medicines you take, including aspirin, especially if you’ve had a stroke. If fever, unexplained weakness or confusion develops, tell your doctor promptly. These may be signs of TTP, a rare but potentially life-threatening condition, reported sometimes less than 2 weeks after starting PLAVIX.

Click here for US Full Prescribing Information Including BOXED WARNING and Medication Guide

Remember, your doctor is the single best source of information regarding your health. Please consult your doctor if you have any questions about your health or your medicine.

What To Do Next: Learn about PLAVIX

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